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Results for "

CFTR Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (15) Autophagy (7) CDK (1) Chloride Channel (1) E1/E2/E3 Enzyme (1) ERK (1) GSK-3 (1) GSNOR (1) Isotope-Labeled Compounds (1) JNK (1) Mitochondrial Metabolism (3) P-glycoprotein (3) Potassium Channel (4) SARS-CoV (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (7) Metabolic Disease (5) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14179

PPQ-102 3 Publications Verification CFTR Inhibitor	CFTR	Others
PPQ-102 (CFTR Inhibitor) is a reversible **CFTR inhibitor** that completely inhibits *CFTR* chloride currents (IC₅₀ ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .

HY-16671

CFTR(inh)-172 5+ Cited Publications	CFTR Autophagy	Others
CFTR(inh)-172 is a potent and selective blocker of the *CFTR* chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a K_i of 300 nM.

HY-19778A

BPO-27 racemate

1 Publications Verification

CFTR Autophagy Inflammation/Immunology

BPO-27 racemate is a potent CFTR inhibitor with an IC₅₀ of 8 nM.

BPO-27 racemate 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
BPO-27 racemate is a potent *CFTR* inhibitor with an IC₅₀ of 8 nM.

HY-18336

GlyH-101 3 Publications Verification	CFTR	Cardiovascular Disease
GlyH-101 is a potent *CFTR* inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current .

HY-14832

Ataluren

5+ Cited Publications

PTC124
CFTR Autophagy Metabolic Disease Cancer

Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

Ataluren 5+ Cited Publications PTC124	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (PTC124) is an orally available *CFTR-G542X* nonsense allele inhibitor.

HY-109027

Cavosonstat N91115	GSNOR CFTR	Inflammation/Immunology
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research .

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses *CFTR* nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-19778

(R)-BPO-27 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive *CFTR* inhibitor with an IC₅₀ of 4 nM.

HY-15206S

Glyburide-d11	Isotope-Labeled Compounds Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3 Glyburide-d₃	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-18337

IOWH-032 3 Publications Verification	CFTR SARS-CoV	Infection Metabolic Disease
IOWH-032 is a a synthetic anti-secretory molecule, is a potent *CFTR* inhibitor with an IC₅₀ value of 8 µM. IOWH-032 also is a anti-diarrheal agent .

HY-N5101

Kobusin	CFTR Chloride Channel	Neurological Disease Inflammation/Immunology
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel .

HY-112363

Aloisine A RP107	CDK GSK-3 ERK JNK CFTR	Inflammation/Immunology Cancer
Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC₅₀s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC₅₀=0.5 μM) and GSK-3β (IC₅₀=1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research .

HY-108575

Chromanol 293B	Potassium Channel CFTR	Cardiovascular Disease
Chromanol 293B is a selective blocker of the slow delayed rectifier K ⁺ current (IKs) with IC₅₀ of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC₅₀ of 19 μM .

HY-15206

Glibenclamide Maximum Cited Publications 18 Publications Verification Glyburide	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-123967

RNF5 inhibitor inh-02	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC₅₀=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research .

Membrane Transporter/Ion Channel Compound Library	1392 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 1392 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5101

Kobusin	Natural Products Source classification Magnoliaceae Magnolia biondii Pamp. Plants	CFTR Chloride Channel
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel .

Cat. No.	Product Name	Chemical Structure

HY-15206S1

Glyburide-d3
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S

Glyburide-d11
Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

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